Recurrent Glioblastoma
Conditions
Interventions
treatment group:Administration of Mifepristone
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. The subject has histologically confirmed diagnosis of primary GBM for which the subject has received surgical intervention of GTR, and postoperative radiochemotherapy of standard Stupp protocol. 2. Clinical presentation consistent with recurrent glioblastoma with measurable enhancing lesions according to RANO criteria; 3. >=18 years of age; 4. Karnofsky performance status (KPS) >= 70; 5. Complete blood count: WBC>4 x 10^9/L, Hb>90g/L; 6. No serious liver or kidney function abnormalities; 7. No significant electrocardiographic abnormalities; 8. No immune system disorders, no history of long-term hormone use within 3 months prior to treatment, non-allergic; 9. Not participating in other clinical trials related to glioma treatment; 10. Consent to join the study, with an informed consent form signed by the patient or a proxy; good compliance and ability to accept follow-up visits and relevant examinations.
Exclusion criteria
Exclusion criteria: 1. Those with contraindications to the use of prostaglandins: e.g. glaucoma, asthma and allergy to prostaglandins 2. Pregnancy with IUD and suspected ectopic pregnancy. 3. Those who are undergoing long-term corticosteroid treatment at the same time. 4. Pregnancy planned within 6 months. 5. Recent use of ketoconazole, itraconazole, erythromycin and other drugs related to metabolism via CYP3A4.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| complete blood count;liver function test;kidney function test;endocrine test;contrast-enhanced brain MR; | — |
Countries
China
Contacts
Public ContactMao Ying
Department of NeurosurgeryHuashan Hospital, Fudan University, Shanghai
Outcome results
None listed