nonalcoholic fatty liver disease
Conditions
Sponsors
the Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. 18-60 years old, BMI >= 24kg/m2, regardless of gender and nationality, right-handed; 2. NAFLD patients diagnosed by MRI-PDFF before randomization; 3. alcohol intake of women is less than 10g/day, and alcohol intake of men is less than 20g/day; 4. No TMS stimulation treatment before; 5. Willing to sign the informed consent form, understand the procedures and methods of this trial, and be willing to strictly abide by the clinical trial protocol to complete this trial 6. Weight stability (± 5%) must be reported for 3 months before participating in the study
Exclusion criteria
Exclusion criteria: 1. Head injury or epilepsy; 2. Metal implants ;Pacemakers and any other contraindications to MRI or rTMS; 3. Weight fluctuation>5% within 3 months; 4. Currently suffering from mental illness or taking antipsychotic drugs; 5. People who use diet pills or very low-calorie diet recently; 6. Eating disorders or material dependence; 7. Presence of diabetes or unstable cardiovascular disease; 8. Pregnant or breast fed; 9. Brain MRI showed abnormal results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRI-PDFF;Fibroscan;body weight; | — |
Secondary
| Measure | Time frame |
|---|---|
| Body Mass Index;waist circumference;lipid metabolism;liver function;HOMA-IR;energy intake;Food craving;brain network activity; | — |
Countries
China
Contacts
Public ContactQiuling Zhang
the Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China
Outcome results
None listed