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Effect of esketamine on perioperative depressive symptoms in patients undergoing hip surgery

Effect of esketamine on perioperative depressive symptoms in patients undergoing hip surgery

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200065589
Enrollment
Unknown
Registered
2022-11-09
Start date
2022-11-21
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

depressive symptoms

Interventions

group K:

Sponsors

Department of Anesthesiology, Beijingsu Xuanwu Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. ASA I~III level 2. Hip surgery patients 3. age over sixty-five years; 4. moderate to severe depressive symptoms evaluated through Patient Health Questionnaire-9 (PHQ-9) and MADRS; 5. Plan to be hospitalized >= 72 h after surgery 6. agree to use patient-controlled intravenous analgesia (PCIA).

Exclusion criteria

Exclusion criteria: 1. ASA >III level; 2. Patients with central nervous system diseases such as Parkinson's, epilepsy, dementia, etc. 3. Patients with severe hepatic and renal insufficiency 4. Severe uncontrolled hypertension, glaucoma, intracranial hypertension 5. pregnancy or lactation; 6. major depressive disorder patients who have received anti-depressants within the past 2 weeks; 7. hyperthyroidism; 8. patients who cannot cooperate to complete psychiatric assessments; 9. unwilling to use PCIA or refuse to participate in this study

Design outcomes

Primary

MeasureTime frame
Response rate to treatment of depressive symptoms on the first postoperative day;

Secondary

MeasureTime frame
Effective rate and remission rate at discharge;

Countries

China

Contacts

Public ContactWang Tianlong

Beijingsu Xuanwu Hospital, Capital Medical University

w_tl5595@hotmail.com+86 15810021355

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026