Tendon and ligament injuries
Conditions
Interventions
Experimental group:Allogeneic tendon
control group:Autogenous tendon
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Subjects should be aged between 18 and 65 (including 18 and 65) and of both genders; 2. Patients with clinically diagnosed anterior cruciate ligament injury requiring surgery; 3. have not participated in other clinical trials within 3 months; 4. Subjects are fully aware of the benefits and risks of this trial, are still willing to participate and sign the informed consent form
Exclusion criteria
Exclusion criteria: 1. Previous history of knee surgery; 2. Patients with severe osteoarthritis (Kellgren-Lawrence grade >= III) and two or more ligament injuries requiring reconstruction and repair; 3. Absence of ipsilateral limb donor ligament; 4. pathological obesity (body mass index [BMI] >= 40); 5. Allergies, such as past medical or family history of autoimmune diseases; 6. Knee tumors, rheumatoid disease, tuberculosis, suppurative disease and complications affecting the joint structure; 7. Secondary knee arthritis accompanied by psoriasis, syphilitic neuropathy brown yellow disease, metabolic bone disease; 8. Frequent users of sedatives, sleeping pills, tranquilizers or other addictive drugs; 9. Patients with serious primary diseases of cardiovascular, cerebrovascular, liver, kidney and hematopoietic systems or mental disorders; 10. Those who cannot accept long-term and complicated rehabilitation training after operation; 11. women during family planning, lactation and pregnancy within 12 months; 12. Mentally incapacitated or unable to understand the requirements of participating in the study, e.g. unable to express, read, and understand the questions in the subject subjective questionnaire specified in the study protocol, and unable to provide feedback in appropriate language 13. Other researchers considered the candidates inappropriate for inclusion, such as failing to evaluate the efficacy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IKDC grading score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Subjective IKDC Knee score;Lysholm scale;Lachman test;Axial shift test;ADT test; | — |
Countries
China
Contacts
Public ContactZhao Jinzhong
Shanghai Sixth People's Hospital
Outcome results
None listed