Postoperative cognitive dysfunction
Conditions
Interventions
Fucoxanthin intervention group(surgica):Fucoxanthin 10mg was given orally twice (once in the afternoon) immediately after the first MMSE score before surgery, and continued on the day of surgery (3 ho
health comparison:Application of placebo
Healthy group (non-surgical):none
Sponsors
The Affiliated Hospital of Medical School,Ningbo University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Clear surgical indication; 2. 65-80 years old; 3. Patients with a total score of 24 or greater as measured by the Mini-Mental State Scale (MMSE). The MMSE score was measured by clinicians with relevant experience and strict training who were responsible for scoring the patients, and the evaluators were responsible for the fixed staff of the project team.
Exclusion criteria
Exclusion criteria: 1. Perennial alcohol addiction, long-term use of drugs affecting mental state; 2. Complicated with severe liver dysfunction and renal dysfunction; 3. Cognitive impairment caused by mental and psychological disorders; 4. language, vision, hearing impairment leads to failure to cooperate with normal examination; 5. Low education level, lack of basic cognitive ability, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| oxidative stress;inflammation;retinoic acid;Retinol Binding Protein;retinoic acid receptor a;retinoic acid receptor ß;retinoic acid receptor ?;hepatic and renal function; | — |
Countries
China
Contacts
Public ContactWu Xiang
The Affiliated Hospital of Medical School,Ningbo University
Outcome results
None listed