Analgesia and sedation
Conditions
Interventions
Sponsors
Zhongda Hospital, School of Medicine, Southeast University
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: Age > 65, no gender limitation; American Society of Anesthesiology (ASA) Grade: I-III; Patients with expected mechanical ventilation time > 48 hours; Signed informed consent.
Exclusion criteria
Exclusion criteria: Patients who had used remifentanil within 24 hours; Known or suspected allergy or contraindication to remifentanil components; Patients with expected survival < 48h; Body mass index (BMI); 30kg/m2 patients; Burn patients; Patients with myasthenia gravis; Bronchial asthma patients; Patients with abdominal compartment syndrome; Patients requiring emergency surgery during the study period; Patients who had used monoamine oxidase inhibitors within the first two weeks of the screening period; Enrolled as a subject in any clinical trial within 1 month prior to the screening period; Those with a history of drug abuse, drug abuse, alcoholism and long-term psychotropic drug use within 2 years prior to the screening period; Pregnant and lactation women; Other conditions deemed unsuitable for inclusion by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Drug concentration - time curve;Area under the concentration-time curve;Apparent volume of distribution;Clearance;Half-life; | — |
Countries
China
Contacts
Public ContactYang Yi
Zhongda Hospital, School of Medicine, Southeast University
Outcome results
None listed