Effects of different doses of intrathecal morphine on quality of postoperative recovery in patients undergoing laparoscopic colorectal surgery

Efficacy of intrathecal morphine on quality of recovery and postoperative analgesia in patients undergoing laparoscopic colorectal surgery: A randomized dose finding study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200065531

Enrollment

Unknown

Registered

2022-11-08

Start date

2022-11-13

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer

Interventions

0.2mg morphine group:Intrathecal 0.2mg morphine + ropivacaine15mg

0.1mg morphine group:Intrathecal 0.1mg morphine + ropivacaine15mg

0.05mg morphine group:Intrathecal 0.05mg morphine + ropivacaine15mg

control group:Intrathecal ropivacaine15mg

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Patients aged 18-75 years old undergoing elective laparoscopic colorectal surgery under general anesthesia 2. American Society of Anesthesiologists (ASA) physical status I to III.

Exclusion criteria

Exclusion criteria: 1. Contraindications for spinal anesthesia, such as the presence of coagulation disorders, anatomical abnormalities, and local infection in the block site 2. history of medication or alcohol abuse 3. Allergy to the study drugs 4. history of chronic pain or intake of any analgesics within 72 hours preoperatively 5. Any other conditions that precluded study inclusion, such as language barrier, preexisting cognitive impairment, declining to participate in any study group.

Design outcomes

Primary

Measure	Time frame
Quality of Recovery-15;	—

Secondary

Measure	Time frame
Quality of Recovery-15;Pain intensity;Time to first analgesic requirement;Intraoperative remifentanil consumption;Morphine equivalents consumption during postoperative 48h;Patient satisfaction on pain management;Time to first flatus;Time to first mobilization;Length of postoperative hospital stay;	—

Countries

China

Contacts

Public ContactYusheng Yao

Fujian Provincial Hospital

fjslyys@fjmu.edu.cn+86 13559939629

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026