Tumor
Conditions
Interventions
propofol:propofol 0.5mg/(kg*min)
Sponsors
Fujian Provincial Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age over 65 years; 2. American Society of Anesthesiologists (ASA) classification II–III; 3. Scheduled for major abdominal surgery under general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Cardiac insufficiency (EF<40% or NYHA classification III to IV); 2. arrhythmias (such as second- or third-degree atrioventricular block or atrial fibrillation); 3. unstable ischemic heart disease; 4. valvular heart disease with significant hemodynamic fluctuations; 5. received pacemaker implantation; 6. body mass index more than 30; 7. predicted or history of difficulty airway; 8. pyloric or high intestinal obstruction; 9. allergic or contraindications to study drugs; 10. history of drug or alcohol abuse; 11. any other conditions that precluded participation judged by the primary investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the baseline MAP over the first 15 min after induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Area under the baseline CI over the first 15 min after induction;Area under the baseline SVRI over the first 15 min after induction;Area under the baseline HR over the first 15 min after induction;Dosage of vasoactive drugs over the first 15 min after induction;Time to loss of consciousness;BIS values at the time of loss of consciousness;Dosage of study drug at the time of loss of consciousness; | — |
Countries
China
Contacts
Public ContactYusheng Yao
Fujian Provincial Hospital
Outcome results
None listed