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To investigate tissue DNA methylation characteristics and correlation analysis with clinical features in patients with laryngeal squamous cell carcinoma: a single-center, prospective study

To investigate tissue DNA methylation characteristics and correlation analysis with clinical features in patients with laryngeal squamous cell carcinoma: a single-center, prospective study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200065498
Enrollment
Unknown
Registered
2022-11-07
Start date
2022-12-01
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

laryngeal squamous cell carcinoma

Interventions

Observation group:none

Sponsors

Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Sign the informed consent voluntarily; 2. Male or female, aged 40-75 years (not including 75); 3. Patients with laryngeal squamous cell carcinoma diagnosed for the first time through tissue biopsy or surgical specimen; 4. The subject has not received any of the following anti-tumor treatments before the collection of tissue samples: tumor surgery for any purpose, local or systemic radiotherapy and chemotherapy, targeted therapy (including anti angiogenesis), immunotherapy, cancer vaccine, hormone therapy.

Exclusion criteria

Exclusion criteria: 1. Female subjects who were pregnant or lactating at the time of sample collection; 2. Have received organ transplantation or non autologous bone marrow or stem cell transplantation in the past; 3. Within 30 days before the collection of samples, they have received drugs with anti-tumor effects due to other diseases, such as methotrexate, cyclophosphamide, mercaptopurine, nitrogen mustard phenylbutyrate, etc., used for immune rheumatic drugs, and tamoxifen, etc., used for breast diseases.

Design outcomes

Primary

MeasureTime frame
Tissue DNA methylatio;

Countries

China

Contacts

Public ContactJiping Li

Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

drlijiping@163.com+86 13764089841

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026