Study on the effect and mechanism of percutaneous acupoint nerve electrical stimulation in postoperative cognitive dysfunction

Clinical study on the effect of transcutaneous electrical acupoint stimulation on postoperative cognitive function and recovery quality in elderly patients

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200065497

Enrollment

Unknown

Registered

2022-11-07

Start date

2022-11-07

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer

Interventions

Group TEAS:percutaneous acupoint nerve electrical stimulation

Group CON:nothing

Eligibility

Sex/Gender

All

Age

60 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Aged > 65 years; 2. Patients undergoing laparoscopic radical surgery for colorectal cancer; 3. No drugs affecting inflammation and immune function were used within 1 month; 4. No skin infection occurs where electrodes are placed.

Exclusion criteria

Exclusion criteria: 1. Cognitive dysfunction before surgery; 2. A past history of delirium; 3. Have mental illness diagnosed by psychiatrist before operation; 4. The disease of central nervous metastasis is not controlled; 5. Uncontrolled grade II or higher hypertension or serious heart disease.

Design outcomes

Primary

Measure	Time frame
MMSE, Mini-mental State Examination;QoR-40, 40-Item Quality of Restoration;cortisol;noradrenaline;D-LAC;DAO;	—

Secondary

Measure	Time frame
TNF-a;IL-6;fMRI;gut microbiome;	—

Countries

China

Contacts

Public ContactYan Lijuan

The First Affiliated Hospital of Xiamen University

yanlijuan0122@126.com+86 15710668779

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026