Postpartum depression
Conditions
Interventions
esketamine group:After delivery of the fetus with umbilical cord severed, 0.25 mg/kg of esketamine was administered intravenously and pumped for 40 minutes. The pumping was completed in 40 minutes.
Control Group:After delivery of the fetus with umbilical cord severed, give 0.05 ml/kg saline intravenous pumping, 40 minutes to complete the pumping
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Pregnant women aged 20-35 years who were to undergo cesarean section under epidural block for full-term singleton pregnancy; 2. Volunteered to join this study and obtained informed consent.
Exclusion criteria
Exclusion criteria: 1. Previous history of mental illness or family history; 2. Pregnant women with complete/partial placenta praevia requiring general anesthesia; 3. Contraindications to epidural block, including poor coagulation, puncture site infection, significant lumbar spine injury, etc.; 4. Allergy to local anesthetics; 5. Severe pregnancy comorbidities, such as uncontrolled hypertension or diabetes mellitus during pregnancy, combined with severe cardiac, hepatic, and renal impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Edinburgh postnatal depression scale (EPDS) score at 6 weeks postoperatively; | — |
Countries
China
Contacts
Public ContactGangming Wu
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed