Oral Lichen Planus
Conditions
Interventions
1:No
Sponsors
West China Hospital of Stomatology, Sichuan University.
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Clinically: 1. The presence of bilateral lesions with a certain degree of symmetry; 2. The presence of a lace-like reticulation (reticular type) composed of gray-white lines slightly above the mucosal surface; 3. It can be manifested as erosive, atrophic, bullous and plaque-type lesions, but there must be a reticular type in other parts of the oral mucosa. Pathologically: 1. The presence of a well-defined, band-like zone of cellular infiltration that is confined to the superficial part of the connective tissue, consisting mainly of lymphocytes; 2. The presence of the signs that liquefaction degeneration in the basal cell layer.
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1. The presence of any other oral mucosal diseases or any other gingival disease; 2. Have a history of treatment with topical or systemic corticosteroids in the past 3 months; 3. The presence of moderate to severe periodontitis in single or multiple teeth: (1) Periodontal pocket depth > 4 mm; (2) Attachment loss > 2 mm; (3) Alveolar bone horizontal or angular resorption, the degree of resorption exceeds 1/3 of the root length; 4. Oral lichenoid lesions: (1) Metal prostheses or silver amalgam fillings are present in the mouth; (2) Patients with a history of suspicious drug use prior to the patient's onset, such as hypoglycemic drugs, angiotensin-converting enzyme inhibitors, and nonsteroidal anti-inflammatory drugs, any suspected drugs that may have caused a mossy reaction; (3) Patients had a history of tumors or were taking various targeted antitumor drugs for tumors; (4) The patient had a history of organ or bone marrow transplantation; (5) The clinical and histopathologic criteria of OLP were partially met, but not completely.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Whether there is congestion and erosion in OLP lesions; | — |
Countries
China
Contacts
Public ContactDan Hongxia
West China Hospital of Stomatology, Sichuan University.
Outcome results
None listed