Cerebral vascular disease
Conditions
Interventions
Drug treatment group:intensive drug therapy
Endovascular treatment group:Endovascular recanalization treatment
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. Non-acute occlusion of intracranial arteries, defined as follows: Time of onset: occlusion time of intracranial arteries > 24 hours; Lesion site: large intracranial arteries (including intracranial arteries) identified by MRA, CTA or DSA Inner segment, M1/M2 segment of middle cerebral artery, A1/A2 segment of anterior cerebral artery, V4 segment of vertebral artery and basilar artery, in the case of vertebral artery V4 segment lesion, bilateral V4 or main blood supply side V4 occlusion is required) occlusion; 3. The clinical symptoms are located in the blood supply area of the occluded arteries, which are characterized by unstable, fluctuating, and progressive symptoms; 4. The blood supply area of the occluded arteries lacks the compensation of the first-order collaterals of the circle of Willis, that is, there is a lack of generation of collaterals passing through the anterior communicating arteries and the posterior communicating arteries to the blood supplying areas on the occluded side; 5. The head MRI scan showed that the area of new infarction in the blood supply area of the middle cerebral artery was less than 1/3; for the occlusion of the internal carotid artery or the middle cerebral artery, CT perfusion imaging showed abnormal perfusion in the corresponding blood supply area (compared with the healthy side), CBF decreased by > 30% or TTP prolonged by > 6 s; for the posterior circulation region, perfusion parameters were not used as reference indicators for ischemia determination).
Exclusion criteria
Exclusion criteria: 1. No arteriosclerotic intracranial vascular disease, such as intracranial arterial dissection, moyamoya disease and vasculitis; 2. Associated with intracranial aneurysm or any bleeding disease; 3. Large-area infarct core area, defined as anterior circulation ASPECTS < 6 points, posterior circulation pc-ASPECTS < 6 points; 4. There is a serious abnormal coagulation; 5. Left ventricular ejection fraction < 30% or hospitalization for heart failure in the first 6 months; 6. Any major surgery, major trauma, revascularization procedure or acute coronary syndrome within the past 1 month; 7. Life expectancy < 1 year due to other diseases; 8. Pregnant or lactating women; 9. Those with contraindications to the use of antiplatelet drugs or iodine-containing contrast agents; 10. Magnetic resonance examination cannot be performed due to internal implants, foreign bodies or claustrophobia; 11. There is a situation in which the neuro-interventional doctor thinks that the interventional operation is not suitable; 12. Unwilling to accept random selection of treatment options, unable to understand and cooperate with research procedures or provide informed consent; 13. Participation in other trials may affect the results of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Any stroke or death within 30 days;New symptomatic stroke/TIA or new ischemic foci on MR imaging (T2, T2 FLAIR or DWI sequences) within 3 months of occluded arterial supply; | — |
Countries
China
Contacts
Public ContactPeng Qi
Beijing Hospital
Outcome results
None listed