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Effects of low-dose esketamine on ED50 and ED95 of propofol and ciprofol for ultrasound-guided prostate biopsy in geriatric patients: a randomized, double-blind, dose-response sequential allocation trial

Effects of low-dose esketamine on ED50 and ED95 of propofol and ciprofol for ultrasound-guided prostate biopsy in geriatric patients: a randomized, double-blind, dose-response sequential allocation trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200065476
Enrollment
Unknown
Registered
2022-11-05
Start date
2022-11-08
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sedation for prostate biopsy

Interventions

propofol group:Sufentanil and propofol
Esketamine and propofol group:Sufentanil, esketamine and propofol
Sufentanil and ciprofol group:Sufentanil and ciprofol
Esketamine and ciprofol group:Sufentanil, esketamine and ciprofol

Sponsors

The First Affiliated Hospital of Soochow University
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
60 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aged >= 60 years; 2. American Society of Anesthesiologists (ASA) physical status I-III; 3. Body mass index(BMI)18-30 kg/m2; 3. Scheduled for ultrasound-guided prostate biopsy.

Exclusion criteria

Exclusion criteria: 1. Serious cardiovascular and cerebrovascular diseases; 2. Severe liver or renal dysfunction (Child Pugh grade C or renal replacement therapy); 3. Severe respiratory diseases; 4. Severe mental and nervous system diseases.

Design outcomes

Primary

MeasureTime frame
ED50 and ED95 of propofol and ciprofol;—

Secondary

MeasureTime frame
Incidence of hypotension;Incidence of respiratory depression;incidence of injection pain;total anesthetic consumption;Incidence of psychiatric effects;—

Countries

China

Contacts

Public ContactPeng Ke

The First Affiliated Hospital of Soochow University

pengke0422@163.com+86 15962155989

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026