Postoperation Sedation
Conditions
Interventions
liver transplantation group:continuous infusion of remimazolam
renal transplantation group:continuous infusion of remimazolam
non-transplant group:continuous infusion of remimazolam
Sponsors
Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years; 2. BMI 19-28 kg/m2; 3. Basic blood pressure: systolic pressure 90-160 mmHg,diastolic pressure 0-100 mmHg; heart rate in peace 50-100 bpm; oxyhemoglobin saturation >= 95% 4. Liver tranplantion patients, renal transplantion patients and other postoperative patients with nomal liver function and kidney function, who's admitted to intensive care unit after suguery; 5. Sign the informed cntract.
Exclusion criteria
Exclusion criteria: 1. Marginal donor liver and liver cancer; Marginal donor kidney, renal cell carcinoma; 2. Intraoperative blood loss > 1000 ml; 3. Preoperative MELD score of liver transplantation patients > 20; 4. Hemodynamic instability during operation requires continuous use of vasoactive drugs; 5. Patients with organ dysfunction other than transplanted organs before surgery; 6. Preoperative electrocardiogram showed prolonged QT time; 7. Known allergy to any benzodiazepine, flumazenil, or study drug excipients (lactose/dextroside 40); 8. Participated in a trial of another study drug within 2 months before or during the study administration; 9. Patients in deep coma who cannot be scored subjectively; 10. Patients with metastatic cancer, affecting liver and renal function metabolism; 11. Patients with myasthenia gravis; 12. Patients who received monoamine oxidase inhibitors within 14 days; 13. Pregnant/perinatal women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| plasma concentration; | — |
Countries
China
Contacts
Public ContactYuan Gao
Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed