postoperative pain
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients of any gender, elective surgery; 2. Aged >= 18 years; 3. Voluntarily participate in the study while signing an informed consent form.
Exclusion criteria
Exclusion criteria: 1. ASA >= Class III; 2. BMI >= 35 kg/m2; 3. Severe cardiac, brain, lung, liver, renal insufficiency; 4. Chronic pain or recent use of analgesic drugs; 5. Pregnant or lactating patients; 6. Patients allergic to study drugs; 7. Mental disorders or alcohol abuse, patients with a history of mental illness, communication disorders and those who cannot correctly understand the investigator's inquiries.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Preoperative pain score;Sleep scores on the night of surgery and the first and second days after surgery;Postoperative adverse evemts (nausea and vomiting, respiratory depression, delirium, arrhythmia, cerebrovascular disease, etc.);Length of hospital stay after surgery;Pain and anxiety at one month after surgery;Preoperative serum 5-HT, brain-derived growth factor, cortisol concentration, norepinephrine concentration;Pain and anxiety at 3 months postoperatively;Pain scores at 30 min, 2 h, 12 h, 48 h and 72 h postoperatively;postoperative consumption of analgesics;intraoperative consumption of analgesics;Preoperative anxiety score; | — |
Countries
China
Contacts
Department of Anesthesiology and Perioperative Medicine, Second Affiliated Hospital of Anhui Medical University