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A prospective randomized control study on the rational use of antibiotics in neonates with bloody stool and intestinal wall gas

A prospective randomized control study on the rational use of antibiotics in neonates with bloody stool and intestinal wall gas

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200065408
Enrollment
Unknown
Registered
2022-11-04
Start date
2022-11-04
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bloody stool of newborn

Interventions

B:No antibiotics
A:Preventive use of antibiotics (cefotaxime sodium) for 3 days

Sponsors

Chengdu Women's and Children's Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Term infants or preterm infants with corrected gestational age greater than 35 weeks; 2. With bloody stool as the main symptom, abdominal film suggested gas accumulation in the intestinal wall; 3. The age of onset was less than 28 days or the corrected gestational age was = 93%; 7. No systemic poisoning symptoms.

Exclusion criteria

Exclusion criteria: 1. The patient is critically ill and the clinical condition is unstable; Neonatal need to use vasopressor > 10 ug/kg/min; Respiratory and circulatory support is required; 2. Imaging examination showed: diffuse gas accumulation in the intestinal wall, gas accumulation in the liver area or the portal vein system inside and outside the liver, pneumoperitoneum, ascites or peritonitis like changes; . 3. Children with congenital developmental abnormalities, chromosomal abnormalities or genetic metabolic diseases; 4. History of antibiotic application within 48 hours before bloody stool; 5. Parents refused to participate in the clinical study.

Design outcomes

Primary

MeasureTime frame
Incidence of depression;

Secondary

MeasureTime frame
Hospital stay;

Countries

China

Contacts

Public ContactYe Zhengwei

Chengdu Women's and Children's Central Hospital

184342784@qq.com+86 28 61866039

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026