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Efficacy and mechanism of rPMS combined with low frequency rTMS on upper limb motor dysfunction post stroke

Efficacy and mechanism of rPMS combined with low frequency rTMS on upper limb motor dysfunction post stroke

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200065403
Enrollment
Unknown
Registered
2022-11-03
Start date
2022-11-15
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

Experimental group:rTMS + rPMS
Control Group:rTMS + rPMS sham stimulation

Sponsors

The Affiliated Third Hospital of Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
25 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Meet the stroke criteria established in 2019, confirmed by CT or MRI as cerebral infarction or cerebral hemorrhage; 2. First onset, hemiparesis of one limb with upper limb motor dysfunction; 3. Duration of disease from 2 weeks to 6 months; 4. Aged 25-75 years; 5. Upper limb Brunnstrom stage between stage I-V, upper limb and hand MAS <= grade 2; 6. Stable vital signs, able to cooperate with treatment and assessment; 7. Patients or their families agree to participate in the trial and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. The following contraindications to transcranial magnetic therapy: intracranial metal implants, cochlear implants, magnetic tablets, pacemakers or cranial defects and upper limb thrombosis; those with a history of seizures or family history of epilepsy; those with severe heart disease or other medical conditions; those with bleeding tendencies; those with open wounds or infections in the treatment area. 2. Patients with major depression, mania and other psychiatric diseases; 3. Patients with serious heart, lung, liver, kidney insufficiency and other complications; 4. Pregnant women and children.

Design outcomes

Primary

MeasureTime frame
Fugl-Meyer Assessment of the Upper Extremity;

Secondary

MeasureTime frame
rest motor threshold;modified Ashworth scale;Functional near-infrared spectroscopy;modified Barthel index;

Countries

China

Contacts

Public ContactXiquan Hu

The Affiliated Third Hospital of Sun Yat-sen University

xiquhu@hotmail.com+86 20 82179022

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026