Quantitative parameters of dual-energy CT in predicting microvascular invasion in primary hepatocellular carcinoma

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200065382

Enrollment

Unknown

Registered

2022-11-03

Start date

2022-11-10

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

primary hepatocellular carcinoma

Interventions

Gold Standard:Pathological diagnosis of liver tumors or surrounding lymph nodes after operation.

Index test:The pathological diagnosis of liver tumors or surrounding lymph nodes was hepatocellular carcinoma with or without microvascular invasion.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Primary hepatocellular carcinoma was confirmed by pathology in patients with clinically diagnosed liver mass; 2. Patients without any treatment before dual-energy CT examination; 3. Patients without contrast-enhanced CT examination contraindications underwent dual-energy CT GSI mode to obtain hepatic plain scan phase, hepatic artery phase, hepatic portal vein phase and hepatic vein phase images; 4. Patients who obtained sufficient pathological tissue samples for pathological examination after operation.

Exclusion criteria

Exclusion criteria: 1. Patients who had received relevant treatment before the first dual-energy CT examination; 2. Patients with contraindicated signs of iodine contrast agent use and other unsuitable for CT scanning; Absolute contraindications: patients with untreated hyperthyroidism; 3. The post-processing of dual-energy CT images cannot be carried out due to poor cooperation of patients, poor image quality due to motion artifacts or other reasons; 4. No four phases were obtained by dual-energy CT GSI model; 5. Incomplete clinical data; 6. Patients who did not obtain enough histopathological specimens or did not undergo pathological testing after surgery.

Design outcomes

Primary

Measure	Time frame
Likelihood ratio test of partial maximum likelihood estimation by forward method;Likelihood ratio test for backward partial maximum likelihood estimation;Optimal subset method;	—

Secondary

Measure	Time frame
Multicollinearity diagnosis;Logistic regression equation;Relative risk;Goodness-of-fit test;	—

Countries

China

Contacts

Public ContactZhang Xiang

Sun Yat-sen Memorial Hospital, Sun Yat-sen University

zhangx345@mail.sysu.edu.cn+86 15820260242

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026