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Efficacy and safety of esketamine combined with midazolam and propofol for painless gastroenteroscopy: a single-center, randomized, double-blind, positive parallel controlled clinical trial

Efficacy and safety of esketamine combined with midazolam and propofol for painless gastroenteroscopy: a single-center, randomized, double-blind, positive parallel controlled clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200065379
Enrollment
Unknown
Registered
2022-11-03
Start date
2022-11-04
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gastrointestinal endoscopy

Interventions

One:Anesthesia of Esketamine Combined with Midazolam and Propofol for Painless Gastroscopy
Two:Anesthesia of Sufentanil Combined with Midazolam and Propofol for Painless Gastroscopy

Sponsors

West China Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Adult patients (aged >= 18 years) scheduled for painless gastroscopy, regardless of gender; 2. Subjects clearly understand and voluntarily participate in this study; 3. Signed informed consent by the subjects themselves, and voluntarily comply with the research process; 4. ASA grade I-II.

Exclusion criteria

Exclusion criteria: 1. Respiratory and / or pulmonary disorders assessed by the researchers as not suitable for participation in the study : those expected to have difficulty in intubation, and those with sleep apnea syndrome; 2. Subjects who received general anesthesia within 7 days before randomization; 3. With heart rate = 160mmHg or = 100mmHg or = 11.1 mmol / L during screening ); 7. Patients who are allergic to medications studied.

Design outcomes

Primary

MeasureTime frame
Incidence of hypoxia (SpO2 < 93 %);

Countries

China

Contacts

Public ContactXiao Wang

West China Hospital, Sichuan University

724572979@qq.com+86 18980601549

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026