Thyroid cancer
Conditions
Interventions
Gold Standard:The test results of the assessment reagent were compared and analyzed with the Sanger sequencing test results to evaluate the clinical accuracy of the assessment reagent. At the same tim
Index test:Evaluation index of assessment reagent and Sanger sequencing method:
(1) Positive compliance rate and its 95% CI
(2) Negative compliance rate and its 95% CI
(3) Total agreement rate and its 95% CI
(4) Kappa value.
Evaluation indicators of assessment reagents and clinical comprehensive diagnosis or histopathological diagnosis:
(1) Sensitivity and 95%CI
(2) Specificity and 95%CI
(3) Accuracy and 95%CI
(4) Kappa value.
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Comprehensive clinical diagnosis information or histopathological results are available; 2. The cytopathological results after fine needle puncture meet one of the following requirements: (1) The benign and malignant thyroid nodules (Bethesda III, V) can not be determined; (2) Patients with thyroid nodules that cannot be identified as benign or malignant (Bethesda IV); (3) Identify patients with malignant (Bethesda VI) thyroid nodules; (4) Identify patients with benign (Bethesda Class II) thyroid nodules.
Exclusion criteria
Exclusion criteria: 1. The samples are not collected, stored and processed according to the specified requirements; 2. The sample does not meet the test requirements; 3. Repeated case samples; 4. Samples that do not meet any of the criteria for inclusion; 5. Samples that the researchers think need to be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gene mutation;Positive coincidence rate and 95% CI;Negative coincidence rate and 95% CI;Total compliance rate and 95% CI;sensitivity;Specificity;accuracy; | — |
Countries
China
Contacts
Public ContactLiu Zhiyan
Shanghai Sixth People's Hospital
Outcome results
None listed