postherpetic neuralgia
Conditions
Interventions
PM group:Morphine patient-controlled analgesia (single injection dose 0.10 mg/kg, lock-in time 4 hours)
PO group:Oxycodone patient-controlled analgesia (single injection dose 0.07 mg/kg, lock-in time 4 hours)
Sponsors
Department of Pain, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-90 years; 2. PHN patients with breakthrough pain (number of outbreaks >= 3 times/day, NRS score at the time of outbreak >= 7); 3. Patients ASA classification I-III; 4. Body mass index 18-27.9 kg/m2; 5. Able to give informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with allergic to morphine or oxycodone; 2. Patients with tumors causing immune deficiency and coexisting postherpetic neuralgia; 3. Patients with obvious decline in cognitive function; 4. Patients with serious physical diseases, including those with high-risk hypertension, respiratory failure, severe liver and kidney insufficiency, and severe cardiac insufficiency, etc.; 5. Pregnant women or nursing mothers; 6. Patients who are unwilling to receive PCIA treatment; 7. Other circumstances that the investigator judges unsuitable to participate in the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| number and duration of breakthrough pain episodes;the dosage of analgesic drugs and the number of rescue analgesia;the NRS score and efficiency before and after medication; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of adverse reactions;length of hospital stay; | — |
Countries
China
Contacts
Public ContactDong Yang
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed