Septic heart disease
Conditions
Interventions
control grop:After the initial injection of 0.1 µg/kg/min normal saline for 2-4h, the injection of 0.2 µg/kg/min normal saline for 20-22h was continued
Levosimentan group:After the initial injection of levosimentan at 0.1 µg/kg/min for 2-4h, the injection was continued at 0.2 µg/kg/min for 20-22h
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with sepsis according to the third edition of the International Consensus on Sepsis and Septic Shock; 2. Aged 18 to 80 years; 3. Cardiac index was less than 2.5 L/min/m2 by echocardiography; 4. Dobutamine and levosimendan therapy were required according to hemodynamic parameters.
Exclusion criteria
Exclusion criteria: 1. Pregnancy; 2. Previous diagnosis of heart failure or reduced ejection fraction; 3. History of heart valve disease or valve replacement and/or heart stent implantation; 4 Severe pulmonary hypertension and cor pulmonale.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Echocardiogram;central venous pressure;Mean arterial blood pressure; | — |
Countries
China
Contacts
Public ContactKeLiang Xie
Tianjin Medical University General Hospital
Outcome results
None listed