Post-radiotherapy cognitive impairment
Conditions
Interventions
Post-radiotherapy cognitive impairment with hydrocephalus:observe and collect related data
Post-radiotherapy cognitive impairment without hydrocephalus:observe and collect related data
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with intracranial mass patients who are not treated surgically and are treated with radiation only, including brain metastases and primary brain tumors; 2. Evaluation at radiotherapy follow-up suggests cognitive decline; 3. Head CT or MRI suggest ventricular enlargement (EI >= 0.3 or z-EI > 0.42); 4. Lumbar wear manometry ICP <= 200 mmH2O and routine cerebrospinal fluid parameters are normal; 5. Tap test (+) or tap test (-) but the symptoms are progressively worse.
Exclusion criteria
Exclusion criteria: Previous or present history of other central nervous system disorders, including but not limited to: head trauma, cerebrovascular disease, Parkinson's disease, Alzheimer's disease, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evans index;z-Evans Index;Intracranial pressure;tap test;Brain/Ventricle Ratio; | — |
Countries
China
Contacts
Public ContactTian Rui
West China Hospital, Sichuan University
Outcome results
None listed