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To explore the expression and clinical significance of NLRP3 in papillary thyroid carcinoma

To explore the expression and clinical significance of NLRP3 in papillary thyroid carcinoma

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200065338
Enrollment
Unknown
Registered
2022-11-02
Start date
2022-07-20
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

papillary thyroid carcinoma

Interventions

Papillary thyroid carcinoma group :no
Papillary thyroid carcinoma adjacent control group:no

Sponsors

Nanjing University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Patients with primary papillary thyroid cancer who received surgical treatment for the first time; 2. No special treatment such as radiotherapy and hormone replacement before surgery; 3. Postoperative routine pathological diagnosis of papillary thyroid cancer; 4. Have complete clinical data; 5. Patients with normal serological inflammation-related indicators; 6. Patients with Hashimoto's thyroiditis combined with papillary thyroid carcinoma; 7. Patients who gave informed consent to this study.

Exclusion criteria

Exclusion criteria: 1. Postoperative pathological diagnosis of thyroid cancer of other pathological types; 2. Thyroid cancer patients who have received radiotherapy, chemotherapy, hormone replacement therapy and other special treatments before surgery; 3. Patients with other systemic malignant tumors (pituitary tumor, colon cancer, gastric cancer, etc.); 4. History of thyroid surgery in the past; 5. Patients with incomplete clinical data or unable to cooperate with the whole research stage; 6. Patients with inflammation, coronary atherosclerosis, cerebral ischemia and other diseases that have been clearly reported to affect the expression of NLRP3; 7. Those who cannot give fully informed consent due to intellectual or behavioral disabilities.

Design outcomes

Primary

MeasureTime frame
NLR Family, Pyrin Domain Containing 3;

Countries

China

Contacts

Public ContactWenbin Shang

Nanjing University of Chinese Medicine

wbshang@njucm.edu.cn+86 13915970480

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026