Heart valve disease
Conditions
Interventions
Group A (propofol group):Immediately after induction, propofol 2-10mg/kg/h and equal volume of normal saline 10mL/h were pumped to maintain moderate sedation until the end of surgery.
Group B (Remimazolam group):Propofol 2-8mg/kg/h and remimazolam 0.2mg/kg/h were pumped immediately after induction to maintain moderate sedation until the end of surgery.
Group C (dexmedetomidine group):Propofol 2-8mg/kg/h and dexmedetomidine 0.3ug/kg/h were pumped immediately after induction to maintain moderate sedation until the end of surgery.
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Cardiac surgery under extracorporeal circulation; 2. ASA grade I-III; 3. Aged 18-65 years, male or female; 4. Heart function (NYHA) grade II~III; 5. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Allergies or contraindications to benzodiazepines, opioids, propofol, naloxone and other drugs and their drug components; 2. The left ventricular ejection fraction was less than 40% before operation; 3. Previous history of cardiac surgery; 4. Patients with severe abnormal cardio pulmonary, hepatorenal systems; 5. Patients with cognitive dysfunction or mental symptoms before operation; 6. There was heart failure within one month before operation; 7. Drug and alcohol addicts; 8. Patients who do not agree to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini mental state examination;Montreal Cognitive Assessment Scale;Monitoring of anesthesia depth;mean arterial pressure;heart rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analog Assessment Scale; | — |
Countries
China
Contacts
Public ContactChen Yanhua
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed