Lung Cancer, COPD
Conditions
Interventions
Gold Standard:Gold standard for lung cancer: pathology.
Gold standard for COPD: pulmonary function tests.
Index test:Hyperpolarized 129Xe MR imaging was obtained for parameters such as percentage of pulmonary ventilation defects, alveolar duct inner diameter, outer diameter, alveolar depth, mean linear in
Sponsors
Shanghai Changzheng Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for healthy volunteers: Aged > 18 years, no history of smoking, normal pulmonary function tests and no respiratory symptoms and diseases, no history of chest surgery. 2. Inclusion criteria for people with lung disease (lung cancer, COPD population) and smoking: Aged > 18 years, and meet any of the following: (1) History of smoking or long-term history of secondhand smoke exposure; (2) Lung nodules detected in the last 1 month without any treatment; (3) Patients with a clear diagnosis of chronic obstructive pulmonary disease; (4) Pulmonary function tests suggesting the presence of small airway dysfunction.
Exclusion criteria
Exclusion criteria: 1. People who are pregnant or lactating; people with a history of chest surgery; 2. People with contraindications to the test methods applied in this study; 3. People with serious primary diseases of the cardiovascular, hepatic, renal and hematopoietic systems; 4. People with psychiatric disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of pulmonary ventilation defects;Inner diameter of the acinar tube;Outer diameter of the acinar tube;Alveolar depth;Alveolar mean linear intercept;Alveolar surface to volume ratio;Gas blood exchange time;Gas blood exchange membrane thickness;Blood residence time;RBC/TP;RBC/Gas;TP/Gas;Volume ratio of the ventilated defective part;effective atomic number;electron cloud density; | — |
Countries
China
Contacts
Public ContactShiyuan Liu, Li Fan
Shanghai Changzheng Hospital
Outcome results
None listed