Mechanisms of calprotectin in intestinal barrier dysfunction due to blood loss in trauma

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200065305

Enrollment

Unknown

Registered

2022-11-01

Start date

2022-10-14

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

trauma

Interventions

Serious injury group:Blood test for calprotectin and Interleukin-22

Minor injury group:Blood test for calprotectin and Interleukin-22

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Trauma patients admitted to the emergency department of West China Hospital within 24h; 2. Aged >18 years; 3. Obtain patient or family consent.

Exclusion criteria

Exclusion criteria: 1. Exclusion of factors that may affect calprotectin elevation such as autoimmune diseases; 2. Inflammatory bowel disease; 3. Liver cirrhosis; 4. Tumors; 5. Gastrointestinal bleeding; 6. Acute infections including respiratory tract infections,Gastrointestinal infections, etc.; 7. Acute coronary syndrome; 8. Heart failure; 9. Pregnant women, lactating women; 10. Daily antiplatelet and anticoagulant medications.

Design outcomes

Primary

Measure	Time frame
calprotectin;Acute gastrointestinal injury;Mortality rate;ICU length of stay;Interleukin-22;	—

Secondary

Measure	Time frame
Mechanical Ventilation;	—

Countries

China

Contacts

Public ContactHu Nie

West China Hospital of Sichuan University

456nh@163.com+86 18980601190

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026