The effect of the injection of phosphorate from the treatment of general anesthesia was used for the study of the effect of general anesthesia in the elderly

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200065299

Enrollment

Unknown

Registered

2022-11-01

Start date

2022-11-01

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Induction of general anesthesia

Interventions

Experimental group:fosphopropofol disodium

The control group:propofol

The control group:etomidate

Eligibility

Sex/Gender

All

Age

65 Years to 75 Years

Inclusion criteria

Inclusion criteria: (1) Age 65-75 years old, both sexes, weight kg=(height -100)±15%; (2)ASA grade I and II; (3) subjects undergoing elective surgery under general anesthesia; (4) non-acute inpatients with proper preoperative preparation; (5) Vital signs: respiratory rate >=10 and =95% while breathing air; Systolic blood pressure (SBP) >=90mmHg and =60mmHg and =55 and <=100 beats/min; (6) able to understand the process and methods of this study, voluntarily participated in and signed the informed consent.

Exclusion criteria

Exclusion criteria: (1) patients with contraindications to general anesthesia or previous history of anesthesia accidents; (2) known or suspected to be allergic or contraindicated to propofol injection, benzodiazepines, opioids, muscle relaxants, etc.; (3) combined with craniocerebral loss, intracranial hypertension, stroke, unstable angina, myocardial infarction; (4) Respiratory insufficiency, obstructive lung disease, presence of a difficult airway, or judgment of difficult tracheal intubation (modified Maanobis scale grade III or IV) (5) uncontrolled diabetes or hypertension; (6) severe liver dysfunction or severe renal insufficiency; (7) history of alcoholism or drug dependence; (8) abuse or long-term use of anesthetic, sedative or analgesic drugs; (9) patients with previous history of mental disorders; (10) those who had participated in any drug clinical trial within 1 month before screening; (11) subjects with any other factors considered by the investigator to be ineligible for participation in the trial.

Design outcomes

Primary

Measure	Time frame
Incidence of Hypotension;	—

Secondary

Measure	Time frame
Blood pressure;Heart rate;The BIS value;Time related measures;Medication use was studied;Satisfaction evaluation of anesthesia induction physicians;Other EFFECTIVENESS MEASURES;Measures OF SAFETY;	—

Countries

China

Contacts

Public ContactJiaqiang Zhang

Henan Provincial People's Hospital

zhangjiq@zzu.edu.cn+86 13737121360

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026