postoperative delirium
Conditions
Interventions
Remimazolam tosilate group: Remazolam combined with remifentanil anesthesia
Sevoflurane group:Sevoflurane combined with remifentanil anesthesia
Sponsors
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 89 Years
Inclusion criteria
Inclusion criteria: (1)Male and female patients aged between 65 and 90 years old; (2) ASA physical status <= ?; (3) Scheduled to undergo excision of colon cancer with expected duration of 2 to 5 hours
Exclusion criteria
Exclusion criteria: (1) Preoperative respiratory dysfunction (PaO2/FiO2<200); (2) Cardiac dysfunction (ejection fraction<50%); (3) The function of important organs is seriously damaged, such as severe liver and kidney dysfunction, pre-operative brain dysfunction, cerebral infarction, and history of cerebral hemorrhage; (4) Low education level, unable to read or cooperate to complete the measurement of neurological function scale,The Mini-Mental State Examination (MMSE) score < 24 before surgery; (5)Allergic history or long-term history of benzodiazepines; (6) The informed consent form for the study was not signed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| anesthesia recovery time;Postoperative nausea and vomiting;Pain score within 3 days after operation; | — |
Countries
China
Contacts
Public ContactYan Tao
Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed