elderly patients undergoing thoracic surgery
Conditions
Interventions
Esketamine group:Propofol 2-4mg/kg/h and esketamine 0.3mg/kg/h were administered with intermittent bolus atracurium
control group:Anesthesia was maintained with propofol at 2-4mg/kg/h and remifentanil at 0.1-0.2µg/kg/min, with intermittent bolus atracurium and sufentanil.
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
65 Years to 75 Years
Inclusion criteria
Inclusion criteria: ASAI-II grade, 65-75 years old, with preoperative diagnosis of lung tumor requiring thoracoscopic single lobectomy and lymph node dissection. Patients had no cognitive impairment (MMSE>24) before the test and had not received anesthesia or surgery in the past 6 months.
Exclusion criteria
Exclusion criteria: 1) suffering from mental illness; 2) organic heart disease, hypertension and arrhythmia; 3) severe liver and kidney diseases; 4) intracranial mass, intracranial aneurysm, intracranial hemorrhage or organic brain damage in the past six months; 5) glaucoma, high intraocular pressure and retinal detachment; 6) difficult ventilation or intubation; 7) severe cognitive impairment before surgery; 8) previous allergy to anesthetic drugs; 9) previous drug or alcohol addicts; 10) those who refused to participate in the experiment; 11) those with low education level could not understand the content of the questionnaire 12) have participated in other clinical trials
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-mental State Examination; | — |
Secondary
| Measure | Time frame |
|---|---|
| vital signs;adverse event rate; | — |
Countries
china
Contacts
Public ContactLeng Zhou
West China Hospital of Sichuan University
Outcome results
None listed