Autoimmune encephalitis
Conditions
Interventions
Experimental group:fecal bacteria transplantation+conventional therapy
Conrol group:conventional therapy
Sponsors
Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: (1) Patients with confirmed autoimmune encephalitis who meet the enrollment criteria. (2) 18 years old <= age <=55 years old, signed and dated written informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients with a diagnosis of human immunodeficiency virus (HIV) infection, brain abscess, viral disease, cerebral malaria, brain tumor, or non-infectious CNS disease (e.g., acute demyelinating encephalomyelitis (ADEM)). (2) Patients with CNS infection with viruses, bacteria, fungi, parasites, or Mycobacterium tuberculosis (TB) (3) Patients with sepsis or systemic inflammatory response syndrome secondary to encephalopathy; patients diagnosed with epilepsy, traumatic brain injury, and/or other neurological disorders prior to the onset of encephalitis (4) Pregnant, lactating women or those who intend to become pregnant in the near future (5) Those who do not agree to sign the patient's informed consent. (6) Participated in another clinical trial within 30 days prior to the date informed consent was obtained, or is participating in another clinical trial; other conditions that, in the opinion of the investigator, make participation in this clinical trial inappropriate. (7) Taking probiotics within 1 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of cognitive impairment at 24 weeks; | — |
Countries
Chain
Contacts
Public ContactHaihong Zhou
Affiliated Hospital of Guangdong Medical University
Outcome results
None listed