Nasopharyngeal Carcinoma
Conditions
Interventions
Intervetion Group (Group A):Intensified nutrition and health education
Routine nutritional consultation
Personalized and customized precise nutrition intervention
Control Group (Group B):Intensified nutrition and health education
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Age: 18-70; (2) Patients with nasopharyngeal carcinoma confirmed pathologically, whose clinical stage is stage II-IV, and who need concurrent radiotherapy and chemotherapy (including targeted therapy); (3) 27.49 >= Body mass index (BMI) >= 15.73 (the highest standard value of Chinese BMI is 23.9 * (100%+15%) and the lowest standard value is 18.5 * (100% - 15%), unit: kg/m2; (4) Functional status score (KPS) >= 70; (5) Blood routine indicators: white blood cell count >= 4.0+9E/L, absolute neutrophil value >= 2.0+9E/L, platelet count >= 100+9E/L, hemoglobin >= 80g/L; (6) Blood biochemical indicators: normal liver function (or total bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST) = 60ml/min, or creatinine <= 1.5 times the upper limit of normal value); (7) No history of serious heart disease or coronary heart disease; (8) Be able to complete the questionnaire related to the research as required; (9) Willing to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Body mass index (BMI) < 15.73 (the lowest standard value of Chinese BMI is 18.5 * (100% - 15%), unit: kg/m2; (2) With other malignant tumors at the same time; (3) Severe digestive system disease; (4) Severe dysfunction of heart, lung, liver and kidney; (5) Severe active infection (including infection); (6) Diabetic patients; (7) Patients with amputation or stent implantation; (8) Other forms of nutrition intervention are being accepted; (9) Refusing to use nutritional supplements or being unable to use nutritional supplements due to allergies; (10) People with mental illness, cognitive impairment, critical patients, pregnant or lactating women, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body composition analysis index;Patient-generated subjected global assessment,PG-SGA;Nutritional risk screening 2002, NRS-2002;The EORTC Core Quality of Life questionnaire,EORTC QLQ-C30;Adverse effects of chemoradiotherapy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Routine hematological indicators (blood routine, blood biochemistry, prealbumin, etc.);Hospitalization expenses; | — |
Countries
China
Contacts
Public ContactLinlin Lu
Peking University Shenzhen Hospital
Outcome results
None listed