Rosacea
Conditions
Interventions
Control group:placebo (30% supramolecular salicylic acid mimic)
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Patients with papulopustular rosacea as a major phenotype according to Standard classification and pathophysiology of rosacea: The 2017 update by the National Rosacea Society Expert Committee (Annex 1); 2) Patients aged between 18-60 years; 3) Patients must agree to participate in the current protocol and sign a written informed consent.
Exclusion criteria
Exclusion criteria: 1) Patients with other facial skin diseases such melisma, freckles and asseborrheic dermatitis, which may affect the determination of the study results; 2) Patients who are allergic to any ingredients of the study drugs or patients with an allergic constitution; 3) Females who are pregnant, planning a pregnancy, or breastfeeding; 4) Patients with acne; 5) Patients taking oral antibiotics (such as minocycline, doxycycline), adrenergic receptor blockers (such as carvedilol) and other drugs for treating rosacea (such as hydroxychloroquine, etc.) during the prior 4 weekspatients taking topical Fusidic acid cream, azelaic acid, brimonidine and other drugs for treating rosacea; patients who had received physical therapy to treat rosacea; patients who had received salicylic acid and alpha-hydroxy acid treatment; 6) Patients taking oral retinoids during the prior 2 months (or oral acitrefin during the prior 6 months); 7) Patients taking topical tacrolimus during the prior 3 months 8) Patients who received facial injection or surgery during the prior 2 months; 9) Patients with immunodeficiency diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lesion reduction rate;Total effective rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Investigator’s Global Assessment (IGA);Investigator Severity Assessement (ISA);VISIA red area value improvement rate; | — |
Countries
China
Contacts
Public ContactXian Jiang
Outcome results
None listed