Impact of opioid-free anaesthesia on postoperative early recovery quality after thoracoscopic surgery - A randomised controlled trial

Study on the application of opioid-free anesthesia in thoracoscopic surgery

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200065209

Enrollment

Unknown

Registered

2022-10-31

Start date

2022-11-01

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Convalescence

Interventions

Experimental group:Opioid-free anaesthesia

Control group:Opioid-based anaesthesia

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Adult patients (more than or equal to 18 yr) who planned for thoracoscopic surgery.

Exclusion criteria

Exclusion criteria: Patients with contraindications to the drugs used in the trial; A history of chronic pain or chronically intake of any analgesics; American Society of Anesthesiologists (ASA) classification more than III; Pregnancy or breastfeeding; Surgery with total regional anesthesia; Outpatient surgery; Symptomatic or third-degree atrioventricular, intraventricular, or sinoatrial block; Adam–Stokes syndrome; Patients chronically treated with beta-blockers and heart rate of fewer than 50 beats/min; Heart failure with a left ventricular ejection fraction of less than 40%; Epilepsy or seizures; A history of obstructive sleep apnea syndrome; Patients with a preoperative oxygen saturation measured by pulse oximetry (Spo2) less than 95%; Severe hepatic impairment (Child-pugh classification C); Severe kidney impairment (endogenous creatinine clearance rate less than 30%) Participation in another interventional trial; Those with conditions that could impact outcome assessment (eg, preoperative cognitive impairment resulting in an Inability to communicate, inability to understand Chinese or English).

Design outcomes

Primary

Measure	Time frame
postoperative pain;Incidence of opioid-related adverse events (nausea and vomiting, respiratory depression, constipation, cognitive dysfunction);	—

Secondary

Measure	Time frame
Incidence of intraoperative bradycardia;Incidence of intraoperative hypotension;Utilization rate of vasoactive drugs;Awakening time;Extubation time;Length of stay in PACU;Postoperative opioid dosage;Patient reported outcome;Patient satisfaction;Unplanned ICU admission rate;Length of stay;	—

Countries

People's Republic of China

Contacts

Public ContactLiu Siyuan

Clinical Medical College & Affiliated Hospital of Chengdu University

liusiyuansc@163.com+86 15023616471

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026