Postpartum depression
Conditions
Interventions
The esketamine group:Intravenous esketamine was administered during cesarean section
The control group:Blank control group
Sponsors
Zhujiang Hospital of Southern Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Age 20-40 years, BMI<= 35 kg/m2; 2. ASA I-II, 36-40 weeks gestation, late pregnancy singleton in utero, placental maturation II+; 3. Voluntary caesarean section and postoperative controlled analgesia; 4. Meet all criteria 1-4 can be included.
Exclusion criteria
Exclusion criteria: 1. Mental instability, abnormal electrocardiogram, hypertension or serious heart disease; 2. History of ketamine or esketamine abuse or dependence; 3. A history of drug or alcohol dependence for more than 6 months; 4. Previous severe adverse reactions to ketamine or es-based ketamine; 5. Prenatal depression; 6. Refusal of written informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postpartum depression (EPDS score); | — |
Secondary
| Measure | Time frame |
|---|---|
| Postpartum pain;Incidence of postpartum adverse reactions; | — |
Countries
China
Contacts
Public ContactLei Hongyi
Department of Anesthesiology, Zhujiang Hospital, Southern Medical University
Outcome results
None listed