cervical cancer
Conditions
Interventions
SK1 group:esketamine(0.25 mg/kg)was injected intravenously at 30 minutes after the surgery started
SK2 group:esketamine(0.5 mg/kg)was injected intravenously at 30 minutes after the surgery started
S1 group:An equal volume of saline was injected intravenously at 30 minutes after the surgery started
Sponsors
Ma 'anshan People's Hospital, Anhui Province, China
Eligibility
Sex/Gender
Female
Age
40 Years to 60 Years
Inclusion criteria
Inclusion criteria: women aged 30-60 years; In accordance with the American Society of Anesthesiologists classification ASA ?-?; Body mass index 27; The patient was approved and volunteered to participate in the study, and the patient signed the informed consent to participate in the study;
Exclusion criteria
Exclusion criteria: Patients with Serious cardiovascular and cerebrovascular diseases and severe hypertension; Preoperative psychiatric abnormalities (including preoperative Zung Self-rating Depression Scale (SDS) score =50), preoperative self-rating anxiety scale (SAS) score =50, Having visual or sensory impairment; Speech impairment or severe hearing impairment; Increased intracranial pressure and intraocular pressure; Long-term or recent oral sedatives, analgesics, non-steroidal drugs, glucocorticoids, psychotropic drugs, or alcoholics, drug addicts; And allergy to any of the drug components in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| micro RNA-132;micro RNA-124;BDNF;Hamilton Depression Scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| 5-HT;IL-6;visual analogue scale;Ramsay sedation score; | — |
Countries
China
Contacts
Public ContactJing Jun
Outcome results
None listed