Ischemic stroke
Conditions
Interventions
Posterior circulation group:Endovascular thrombectomy
Anterior circulation group:Endovascular thrombectomy
Sponsors
Shandong Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1)Patients with acute ischemic stroke; 2)Aged = 18 years; 3)mRS 0–1 before the onset; 4)occlusion site at ICA, M1, M2, VA or BA on CT angiography or MR angiography 5)ASPECTS =3 on CT or DWI of MRI; 6)Within 6 hours of onset or 6-24 hours after onset with indication for endovascular treatment according to multimode imaging evaluation.
Exclusion criteria
Exclusion criteria: 1)Evidence of acute intracranial hemorrhage on CT or MRI; 2)Clinically confirmed or suspected chronic occlusion or dissection with the responsible vessel; 3)Women with pragnancy or in lactation period; 4)Known allergy (more severe than skin rash) to contrast agents; 5)High risk of hemorrhage (platelet 50 second or PT-INR > 3.0), history of coagulation disorder, systemic haemorrhage, thrombocytopenia or neutropenia; 6)Patients with serious or fatal comorbidities (liver and kidney dysfunction, cardiopulmonary dysfunction, life expectancy less than 3 months, etc.) for whom the investigator judged that intravascular therapy was not appropriate; 7)Patients who in the judgment of the investigator, are likely to be non-compliant or uncooperative during the study due to various reasons such as mental illness, cognitive or emotional disorders, etc. 8)Significant mass effect with midline shift on CT or MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Achievement of mRS 0–3 at 90 days;Successful recanalization confirmed by DSA(TICI 2b/3 grade); | — |
Secondary
| Measure | Time frame |
|---|---|
| Achievement of mRS 0–2 at 90 days;Achievement of mRS 0–1 at 90 days;One scale shift of mRS (shift analysis);NIHSS improvement of = 8 points at 48 hours;NIHSS at 90 days;ED-5Q at 90 days;Achievement of TICI 2b-3;Achievement of TICI 2b-3 after the first pass;Mean procedure time;Mean number of passes;Mean time from puncture to recanalization; | — |
Countries
China
Contacts
Public ContactQinjian Sun
Shandong Provincial Hospital
Outcome results
None listed