Allergic Diseases
Conditions
Interventions
Allergic rhinitis group:
Asthma group:Sample collection
Allergic rhinitis with asthma group:Sample collection
Atopic dermatitis group:Sample collection
Health examination group:Sample collection
Sponsors
Department of Pediatrics, Xijing Hospital, The Air Force Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 14 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for children with allergic diseases (200 cases): (1) Age 0-14 years; (2) The children with allergic diseases had a history of allergic reaction in the past 1 year; (3) It meets the international diagnostic criteria for children's allergic diseases, allergic asthma, allergic diseases with asthma, and atopic dermatitis: The diagnostic criteria for children with allergic rhinitis (50 cases) should be based on their family history, typical allergic history, clinical manifestations and laboratory test results consistent with them. ? Symptoms: sneezing, clear runny nose, nasal itching and nasal congestion in 2 or more cases. The symptoms last or accumulate for more than 1 hour every day, and may be accompanied by respiratory symptoms (cough, wheezing, etc.) and eye symptoms (including itchy eyes, tears, red eyes, burning sensation, etc.) and other accompanying disease symptoms. ? Signs: common nasal mucosa is pale, edematous, and nasal cavity is watery. ? Laboratory test: at least one allergen SPT and (or) serum specific IgE are positive; ? Because the negative rate of SPT or serum specific IgE test in infants is high, and the incidence of non allergic diseases in infants is low, the diagnosis of AR in infants, skin pricking or serum specific IgE test may not be necessary conditions, but can be diagnosed only according to allergy history, family history, typical symptoms and signs. The diagnosis of asthma is mainly based on respiratory symptoms, signs and pulmonary function tests, which confirm the existence of variable expiratory airflow restriction, and exclude other diseases that can cause related symptoms. ?Repeated wheezing, coughing, shortness of breath and chest tightness are mostly related to exposure to allergens, cold air, physical or chemical stimulation, respiratory tract infection, exercise and hyperventilation (such as laughter and crying), which often occur or worsen at night and/or in the morning. ?During the attack, scattered or diffuse wheezing sounds can be heard in both lungs, mainly in the expiratory phase, and the expiratory phase is prolonged. ?The above symptoms and signs were effectively or spontaneously relieved by anti asthma treatment. ?Except wheezing, coughing, shortness of breath and chest tightness caused by other diseases. ?Those with atypical clinical manifestations (such as no obvious wheezing or wheezing) should have at least one of the following: (1)It is confirmed that there is reversible airflow restriction: ?Positive bronchodilation test: after 15 minutes of inhaled the quick results ß2 receptor agonists (such as salbutamol quantitative aerosol 200-400 µg), the Forced Expiratory Volume (FEV1) in the first second increased by = 12%; ?The pulmonary ventilation function improved after anti-inflammatory treatment: after 4 weeks of inhaled glucocorticoid and/or antileukotriene treatment, FEV1 increased by = 12%; (2)Bronchial provocation test was positive;(3)The mean value of maximum Peak Expiratory Flow (PEF) diurnal variation rate (continuous monitoring for 2 weeks) was = 13%. Those conforming to 1-4 or the 4 and 5 can be diagnosed as asthma. Inclusion criteria for children with allergic rhinitis and asthma (50 cases): The children met both the inclusion criteria for allergic rhinitis and allergic asthma; Inclusion criteria for children with atopic dermatitis (50 cases): Mainly according to Williams diagnostic criteria: skin itching lasting for 12 month
Exclusion criteria
Exclusion criteria: Exclusion criteria: ?Upper respiratory tract infection, chronic obstructive pulmonary disease, emphysema, bronchiectasis, tuberculosis, pneumonia, secretory otitis media; ? History of other allergic diseases, including food allergy and allergic asthma; ? Organic heart disease or ECG changes with clinical significance; ? Thyroid disease, epilepsy history, liver and kidney dysfunction, hematopoietic dysfunction, gastrointestinal diseases, patients with malignant tumors, autoimmune diseases; ? The patient has a history of mental and nervous system diseases; ? Patients who received the following treatments before clinical trials: immunotherapy and PPI within 12 months, patients with probiotics, prebiotics or synbiotics use history within 2 months, systemic or local glucocorticoids (inhalation or nasal spray) within 2 weeks, antibiotics within 2 weeks, long-term antihistamines within 2 weeks, short-term antihistamines within 1 week, systemic or local nasal decongestants within 24 hours Anticholinergic and antiarrhythmic drugs. Health children (30 cases): healthy children without allergic disease or infection history.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composition and function of respiratory tract flora, skin flora and intestinal flora;Serological detection of IL-4, IL-5, IL-10, IL-13, IL-17A, IFN- ? And specific IgE concentration;Allergen and FeNO;Number of eosinophils and neutrophils in blood;Pulmonary function; | — |
Countries
China
Contacts
Public ContactXin Sun
Xijing Hospital
Outcome results
None listed