osteosarcoma
Conditions
Interventions
osteosarcoma group:None
Sponsors
The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
5 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.hospitalized patients diagnosed as acute lymphoblastic leukemia (ALL), non-Hodgkin lymphoma, osteosarcoma; 2.the age of patients from 5 to 70; 3.the chemotherapy regimen is included high-dose MTX;4.the whole chemotherapy regimen with HD-MTX is under therapeutic drug monitoring; 5.the liver and kidney functions are normal before chemotherapy, and the hepatitis B surface antigen is negative.
Exclusion criteria
Exclusion criteria: 1.pregnant women and/or patients without high-dose MTX; 2.patients with severe liver diseases such as viral hepatitis, liver cirrhosis, drug-induced liver damage, and liver cancer upon admission; 3.patients who stopped HDMTX treatment due to severe adverse reactions or other reasons; 4.the case of patient is incomplete or none in the medical record system; 5.drinking and/or smoking.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Genetic mutations;Liver function parameters;Blood routine examination;Plasma concentration; | — |
Countries
China
Contacts
Public ContactCai Hualin
The Second Xiangya Hospital, Central South University
Outcome results
None listed