Effect of living style on the concentration of histone acetylase in cerebrospinal fluid and postoperative cognitive dysfunction in the elderly

Status

Active, not recruiting

Phases

Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200065102

Enrollment

Unknown

Registered

2022-10-27

Start date

2022-10-27

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative cognitive dysfunction

Interventions

live alone:none

live with spouse:none

live with children:none

live with spouse and children:none

Eligibility

Sex/Gender

All

Age

60 Years to 110 Years

Inclusion criteria

Inclusion criteria: 1. 60 years old and above; 2. Perform radical surgery for colorectal cancer and require general anesthesia combined with spinal anesthesia.

Exclusion criteria

Exclusion criteria: 1. Previous history of cognitive impairment related diseases or preoperative MMSE score 1; 2. Those who are speechless, deaf, blind, or unable to communicate normally with others due to other physical illnesses; 3. Individuals with current or past mental disorders; 4. Currently using sedatives or antidepressants; 5. Alcoholic patients. All patients cannot be included twice, even if they have undergone an unrelated second surgery.

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative cognitive dysfunction;	—

Countries

China

Contacts

Public ContactJun Geng

Jiangyin Hospital Affiliated to Nantong University

alinaglz@163.com+86 18861667601

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026