The role of peripheral blood mononuclear cell pyroptosis in delirium after cardiac surgery

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200065098

Enrollment

Unknown

Registered

2022-10-27

Start date

2022-10-31

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative delirium

Interventions

Postoperative delirium group (POD group), no postoperative delirium group (no POD group) :None

Healthy control group:None

Eligibility

Sex/Gender

All

Age

65 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients selected for cardiac surgery under cardiopulmonary bypass, aged 65~80 years, American Association of Anesthesiologists classification II or III, with a height of 155~185 cm and a weight of 45~85 kg.

Exclusion criteria

Exclusion criteria: Left ventricular ejection fraction<50%; Previous history of cardiac surgery; Have a history of serious coronary heart disease, hypertension, diabetes and nervous and mental system diseases; Severe pulmonary or systemic disease; Diagnosed dementia, Parkinson's disease and stroke; Take psychotropic drugs for a long time; Cardiac block and other serious arrhythmias; Hypothyroidism; Severe hepatic and renal insufficiency; Taking sedatives, analgesics or antidepressants recently.

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative delirium;	—

Countries

China

Contacts

Public ContactZhou Junhui

Henan Provincial Chest Hospital

zhoujunhui1985@126.com15803865536

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026