Respiratory system complications in patients undergoing tonsillectomy and/or adenoidectomy
Conditions
Interventions
D:Sufentanil 0.35ug/kg
C:Sufentanil 0.3ug/kg
A:Sufentanil 0.2ug/kg
B:Sufentanil 0.25ug/kg
Sponsors
Yichang Central People's Hospital of Hubei Province
Eligibility
Sex/Gender
All
Age
3 Years to 15 Years
Inclusion criteria
Inclusion criteria: 1) Age: 3-15 years old; 2) ASA class I or II; 3) Estimated anesthesia operation time <= 120min; 4)BMI 14~23.9kg/m^2
Exclusion criteria
Exclusion criteria: 1) Patients with a history of opioid allergy; 2) Analgesics, sedatives, emetics and anti pruritus drugs were used 24 hours before operation; 3) Patients with body temperature higher than 38 degree within 24 hours before operation or with symptoms of acute upper respiratory tract infection; 4) Patients with a history of bronchial asthma; 5) Patients diagnosed with moderate to severe sleep apnea syndrome before operation; 6) Patients with difficult airway or previous abnormal anesthesia recovery history were evaluated before operation; 7) Renal function injury (BUN and or Cr > upper limit of normal value); 8) Liver function injury (ALT and or ast > 1.5 times the upper limit of normal value); 9) Patients with severe head trauma and intracranial hypertension within 6 months; 10) Patients with mental and neurological diseases, or unable to correctly express their wishes; 11) Patients with long-term sedative and analgesic drugs or monoamine oxidase inhibitors; 12) The estimated blood loss is more than 100ml; 13) Those who have participated in clinical trials of other drugs in recent one month; 14) Patients who can't score ASA or flacc for various reasons; 15) With other conditions, the researchers believe that it is not suitable for the selected patients. 16) Abnormal breath holding test. 17) I haven't quit smoking in the last half month. 18) Patients with hypertension or accompanied by arrhythmia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The grade for SIC;The grade for EIC;Score for Throat pain;ED50 for SIC;ED50 for EIC;ED50 for Throat pain;Incidence of analgesic use;Incidence of PONV; | — |
Secondary
| Measure | Time frame |
|---|---|
| Score for Throat pain in 24h;Hemodynamic parameters within five minutes after induction of intubation;Hemodynamic indexes within five minutes after extubation;Time for extubation; | — |
Countries
China
Contacts
Public ContactGong Yuan
Yichang Central People's Hospital of Hubei Province
Outcome results
None listed