Safety and efficacy evaluation of inhaled anesthetics
Conditions
Interventions
Desflurane group:desflurane(1.0MAC mask +1.5 MAC intubation)
Sevoflurane group:sevoflurane (1.0MAC mask+1.5 MAC intubation)
Sponsors
Zhongnan Hospital of Wuhan University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. ASA Class I-II. 2. Patients aged >18 years and <75 years old. 3. Elective patients undergoing breast tumor resection under general anesthesia. 4. Voluntarily participate in this trial and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Heart disease (e.g.,pacemaker placement, frequent arrhythmias, atrial fibrillation,); 2. Patients with respiratory dysfunction (emphysema, pulmonary fibrosis, bullae, COPD and other respiratory diseases); 3. Enter the operating room and measure basal blood pressure >=140/90mm Hg 2-3 times continuously; 4. Patients who take sedative, analgesic and psychotropic drugs for a long time; 5. Patients who drink alcohol or drugs for a long time; 6. neuromuscular diseases (specifically amputation, myasthenia gravis); 7. Patients who did not sign the informed consent, or patients who refused to join the clinical trial after signing the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the safety and efficacy of desflurane as compared with sevoflurane for induction and maintenance of anesthesia with mask oxygen (1.0MAC) and with endotracheal intubation (1.5MAC);Incidence of respiratory depression and respiration curve;Incidence of arrhythmia and ECG; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of low oxygen saturation;rSO 2;EEG; | — |
Countries
China
Contacts
Public ContactZongze Zhang
Zhongnan Hospital of Wuhan University
Outcome results
None listed