Effect and mechanism of intraoperative individualized PEEP and tidal volume on atelectasis after one-lung ventilation

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200065071

Enrollment

Unknown

Registered

2022-10-27

Start date

2022-11-01

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Study on perioperative organ injury and protection

Interventions

one:traditional PEEPand tidal volume

two:individualized tidal volume

three:individualized peep

four:individualized PEEP and tidal volume

Eligibility

Sex/Gender

All

Age

18 Years to 68 Years

Inclusion criteria

Inclusion criteria: 1. Thoracoscopic lobectomy was performed from October 2022 to April 2023; 2. Both sexes; 3. Aged 18-65 years; 4. BMI: 19-28kg/m^2; 5. Preoperative ASA score I-II; 6. The cardiopulmonary function is basically normal; 7. No obvious heart, liver, kidney or endocrine diseases; 8. Informed consent of the patient.

Exclusion criteria

Exclusion criteria: 1. Acute lung infection in the past 4 weeks; 2. Previous pulmonary surgery history; 3. Have used hormone drugs before operation (within 6 months); 4. Pleural effusion before operation; 5. Intraoperative one-lung ventilation time less than 1 hour; 6. Severe intraoperative complications such as massive bleeding and anaphylactic shock; 7. Converted to thoracotomy; 8. The patient refused midway.

Design outcomes

Primary

Measure	Time frame
Percentage of atelectasis area;	—

Secondary

Measure	Time frame
oxygenation index;inflammatory marks;	—

Countries

China

Contacts

Public ContactZhongmeng Lai

Fujian Medical University Affiliated Union Hospital

463750491@qq.com+86 15980530160

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026