Periodontitis
Conditions
Interventions
1:Live Lactobacillus fermentum CCFM1139
2:Inactivated Lactobacillus fermentans CCFM1139
3:Live Lactobacillus rhamnosus CCFM1138
5:Baseline examination and sample collection
Sponsors
Wuxi Stomatological Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-65 years old; 2. Patients with periodontitis: Stage II periodontitis (European Union of Periodontology and American Society of Periodontology new classification), PD<=5 mm, maximum interdental attachment loss: 3 mm<=CAL<=4 mm, X-ray alveolar bone resorption extends to 1/3 of the root crown, and no tooth loss due to periodontitis. The healthy group: 24 natural teeth (excluding the third molar)at least; PD <= 3 mm, BOP positive sites less than 10%; No induced oral factors caused local irritation and plaque retention; There were no imaging signs of clinical attachment loss or alveolar bone destruction, and no history of periodontitis; 3. The lifestyle remained unchanged and healthy during the study period.
Exclusion criteria
Exclusion criteria: 1. Have periodontal treatment or antibacterial treatment related to the cause in the past 6 months; 2. Have systemic diseases that may affect the progression or treatment response of periodontitis (such as respiratory diseases, type 1 and type 2 diabetes); 3. Smokers; 4. Have routine dental surgery that requires prophylactic antibiotic treatment; 5. Long term using of anti-inflammatory drugs; 6. Use probiotics 2 months before the study; 7. Pregnant or lactating women; 8. Fail to follow the oral hygiene instructions provided or / and maintain regular appointments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical attachment loss;probing depth;plaque index;bleeding index;bleeding on probing; | — |
Countries
China
Contacts
Public ContactFeng Chenchen/Cui Shumao
Outcome results
None listed