surgery patient
Conditions
Interventions
Monotherapy group:Ropivacaine
Composite group:Esketamine combined with ropivacaine
Sponsors
The First People's Hospital of Lianyuangang
Eligibility
Sex/Gender
All
Age
55 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients must meet all of the following inclusion criteria to be included in this study: 1. 55 <= age <=75 years old, regardless of gender; 2. Elective knee replacement surgery; 3. ASA grade I or II; 4. 18 kg/m^2 < BMI<30kg/m^2; 5. Clearly understand and voluntarily participate in the study, and sign the informed consent form by himself/herself
Exclusion criteria
Exclusion criteria: Patients with any of the following were not eligible for this study: 1. Emergency surgery; hypovolemia, shock, or coma; 2. Planned spinal or epidural anaesthesia; 3. Infectious heart disease such as myocarditis or cardiac Endocarditis; sepsis; 4. Abnormal coagulation function (PT or INR >= 1.5*ULN, APTT >= 1.5*ULN); 5. Abnormal liver function, AST and/or ALT >= 2.5*ULN, TBIL >= 1.5*ULN; 6. Abnormal renal function, urea or urea nitrogen >= 1.5*ULN, serum creatinine greater than the upper limit of normal; 7. Acute heart failure; Unstable angina; myocardial infarction within 6 months before screening; resting ECG heart rate = 450 ms for males, >= 470 ms for females; 8. Hypertensive patients with unsatisfactory control of blood pressure (sitting systolic blood pressure >= 160 mmHg, and/or diastolic blood pressure >= 100 mmHg during screening); 9. Sitting systolic blood pressure = 11.1 mmol/L during screening); 11. Screening History of drug and/or alcohol abuse in the previous 2 years, which means drinking more than 2 units of alcohol per day on average (1 unit = 360 mL of beer or 45 mL of liquor with 40% alcohol content or 150 mL of wine); 12. Suffering from mental illness Systemic diseases (schizophrenia, mania, bipolar disorder, mental disorder, etc.) and long-term use of psychotropic drugs and cognitive dysfunction; 13. Esketamine, opioids, propofol, muscle relaxants Those who are allergic to or have contraindications to other drugs and their drug components; 14. Patients who are judged to be difficult to manage the respiratory tract (modified Markov score is grade IV); 15. Other situations that the investigator considers inappropriate to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS; | — |
Countries
China
Contacts
Public Contactchengzhi
The First People's Hospital of Lianyuangang
Outcome results
None listed