Tobacco dependence
Conditions
Interventions
Intervention group:using tobacco heating system to smoke cigarettes
Control group: continue smoking cigarettes by burning
Sponsors
Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.aged 18-60 years 2.have the ability to using smartphone 3.BMI 18.5-32.0 kg/m2 4.self-reported regular smoking for at least 1 year, smoke at least 10 cigarettes per day 5.not willing to quit smoking or willing to quit but does not plan to quit smoking in the next 6 months 6.willing to use tobacco-heated device to smoke cigarettes 7.could complete the follow-ups and sign the informed consent
Exclusion criteria
Exclusion criteria: 1.patients with chronic respirtory diseases, including asthma (FEV1/FVC =12% or 200ml), COPD (FEV1/FVC <= 0.75 after inhaling bronchodilators), bronchiectasis, interstitial lung diseases etc. 2.patients with unstable angina, acute myocardial infarction, stroke and transient ischemic attack in recent 2 weeks, hypertension and arrhythmia with poor drug control, etc. 3.patients with rhinitis, pharyngitis and laryngitis etc. 4.patients with cancer 5.patients with severe allergy 6.patients with psychological problem 7.patients with acute diseases (such as acute upper respiratory tract infection) 8.using nicotine replacement therapy or other smoking cessation medication 9.using other tobacco products except cigarettes, including e-cigarettes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes of urinary biomarkers of tobacco-related harmful substances at 7-day follow-up;percentage of smokers who self-reported willing to quit in the next 1 month; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes of urinary biomarkers of tobacco-related harmful substances at 21-day follow-up;Changes of biomarkers in blood at 21-day follow-up;Changes of Exhale-CO level at 21-day follow-up;percentage of smokers who self-reported having reduced smoking cigarettes at 21-day follow-up;scores of smoking desire and withdrawal symptoms at the 7-day and 21-day follow-ups;satisfaction and acceptability of tobacco heating system; | — |
Countries
China
Contacts
Public ContactLi Xiaobo
Capital Medical University
Outcome results
None listed