Patients requiring mechanical ventilation in the ICU
Conditions
Interventions
remimazolam besylate:The sedative drug was changed to remimazolam benzenesulfate 12 hours before SBT test: loading dose 0.2mg/kg, maintenance dose 0.1-1.0mg/kg/h
Conrol group:12 hours before SBT test, sedatives were converted to:Midazolam loading dose 0.03-0.3mg/kg, maintenance dose 0.04-0.2mg/kg/h
Sponsors
Xijing hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)age;18-80 years 2) First admission to ICU; 3) Intubated patients who are expected to receive mechanical ventilation for =24 hours in the ICU; 4) Informed consent was obtained from patients or family members.18-80
Exclusion criteria
Exclusion criteria: 1. known or suspected allergy to the test drug ; 2. pregnant and lactating women ; 3. Severe obesity ( BMI >= 35 kg/m2 ) ; 4. Chronic liver and kidney dysfunction: chronic liver failure: Child-pugh improved classification of 10-15 points ( C grade ); chronic renal failure: KDIGO diagnostic criteria >=CDK3 [stage 4 [ GFR or eGFR 15-29 mL/( min 1.73m2 )] and stage 5 [ GFR or eGFR < 15 mL/( min 1.73m2 )], eGFR was calculated using the modification of diet in renal disease study ( MDRD ) formula: eGFR = 170*serum creatinine (SCr) -1.234*age -0.179*0.79 (female)] 5. history of alcoholism or taking anti-anxiety drugs or hypnotics ; 6. Patients with expected difficulty in weaning ( such as high spinal cord injury or advanced amyotrophic lateral sclerosis ) ; 7. Coma due to craniocerebral trauma, status epilepticus and unknown etiology ; 8. patients who stopped treatment due to poor prognosis ; 9. Patients who participated in other studies within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time from cessation of sedation administration to extubation; | — |
Countries
china
Contacts
Public Contactzhangxijing
Xijing hospital
Outcome results
None listed