Heart failure with mildly reduced ejection fraction
Conditions
Sponsors
Xi'an International Medical Center Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Obtain the informed consent of the subjects; 2. Ages ranged from 18 to 65 years old; 3. Patients diagnosed with heart failure (NYHA II-III) and LVEF>40%; 4. N-terminal pro B-type natriuretic peptide >= 125pg/mL; 5. And meeting at least one of the following criteria: (1)Left ventricular hypertrophy and/or left atrial enlargement; (2)Abnormal diastolic function.
Exclusion criteria
Exclusion criteria: 1. Severe acute decompensated heart failure, severe valvular heart disease, congenital heart disease, acute myocardial infarction, acute coronary syndrome, symptomatic arrhythmia; 2. Severe hepatic and renal insufficiency, eGFR = 180mmHg and/or symptomatic hypotension and/or systolic blood pressure <100mmHg at screening, regardless of whether receiving antihypertensive drug treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Early diastolic filling ratio;End-diastolic volume;N-terminal pro B-type natriuretic peptide; | — |
Secondary
| Measure | Time frame |
|---|---|
| Minnesota quality of life scale for cardiac insufficiency;6-minute walking test; | — |
Countries
China
Contacts
Public ContactYan-Ni Yao
Xi'an International Medical Center Hospital
Outcome results
None listed